Dr. Pierre Drapeau (pictured above) and team of Université de Montréal recently published an important paper in JCI Insight showing how basic animal models are used to identify ALS potential therapeutics. They found that pimozide, a neuroleptic drug, was the most potent in impacting animal model mobility. A short clinical trial was then conducted in sporadic ALS patients, which demonstrated that the drug hit its target and safe at a specific dose. Evidence from these studies paved the way for the current randomized pimozide phase II clinical trial that began enrollment this month in Canada. We are proud to support these studies through the Lawrence and Isabel Barnett Drug Development Program, and your donations.