Challenge Me to Halt the Progression of ALS

By Stanley Appel, M.D.
Co-director, Houston Methodist Neurological Institute
Chair, Stanley H. Appel Department of Neurology

I call ALS “the nice guys’ disease.” For, as indiscriminate as it appears, ALS certainly has a way of finding the best and most courageous people to attack. Watching people endure the wasting of their muscle control and seeing them defiant in the face of the sure and steady loss of communication and independence, makes me defiant too. People with ALS fight the disease with great courage. Seeing the fire and determination of my patients inspires me every day. Our team puts that inspiration to work in the clinic and in my lab, where we are on a promising path to finding effective therapies to slow ALS.

The money you generated by accepting the ALS Ice Bucket Challenge has changed the treatment and care landscape for people living with ALS. It has funded groundbreaking research, giving the medical and pharmaceutical communities more insight into how ALS progresses. These discoveries help us narrow treatment targets that we can test in our labs – and in more clinical trials – in more places across the country. In fact, The ALS Association has been able to increase the number of Certified Treatment Centers of Excellence by 29 and Recognized Treatment Centers by 20. This makes better care more accessible to more people fighting ALS.

Thanks to money raised through the ALS Ice Bucket Challenge, we have been able to open a new avenue of study into the immune system’s response to damage to the nerve cells in the central nervous system. We’ve been able to acquire an incredible amount of data pointing to the dysfunction of regulatory T-cells in the immune systems of people with ALS, and have learned how to expand the regulatory T-cells to restore the functions. Preliminary studies suggest that infusion of these expanded cells back into the ALS patients from which they were derived was safe and well tolerated and can potentially slow disease progression.

We have the potential to transform ALS from a 100 percent fatal disease to a manageable, chronic disease like diabetes. This is an unprecedented time in the ALS research and treatment community and it is due in great part to people like you who answered the Challenge and joined the fight to end ALS.




The Challenge Me campaign picks up where the ALS Ice Bucket Challenge left off. This time, the ALS community is challenging everyone to do anything and everything they can to cure ALS. Click here to learn more.

22 thoughts on “Challenge Me to Halt the Progression of ALS”

  1. Please, I would like to stop the progression of ALS in my big sister. I live in Canada. Where can she get the treatment that the three people
    got from Dr. Stanley Appel in order to halt this disease. She just turned 60 and otherwise she was a fit, happy woman that never was sick from the flu or anything else. Please please help us.
    Colleen Gockel

    Liked by 1 person

    1. My recommendation is to try to get into the Brainstorm stem cell clinical trial. If you research online there are some people reporting improvements, which is rather unheard of in ALS. My father, who was diagnosed last year, is unfortunately too old, I think their cut off age is 75 or 80.
      Another new Avenue seems to be Ibudilast in combination with Rilutek. Ibudilast is still in clinical trial here, but already admitted in Japan for MS and asthma. Seems to have produced some good results also. Sorry, that’s all I know. I am spending half an hour every day online to find something. Sending my prayers for all who got this terrible disease.


  2. Thanks a lot but in my country there are no trials. If there will be an omologate drug to receive also in Romania that is thanksfull. Have a lot of nice days


  3. doctor- you hit the nail on the head, ALS does seem to befall those who are the “BEST” !!
    My son has the disease and I pray every minute that there might be hope for a miracle!
    Would it not be absolutely wonderful to be able to control this wicked disease as other chronic illnesses are!!

    Liked by 1 person

  4. If this treatment was so successful for these three patients is there any possibility for individuals to pay for their own treatment or is the cost really that prohibitive? This sounds so promising.

    Liked by 1 person

  5. Another challenge…make the treatment available at a reasonable cost for patients asap. They need help now! It is too late for my mom, don’t make it too late for others.


  6. Sir, please tell me how can I get this treatment for my grandmother.
    I am from India. Please tell about the clinical trials.


  7. Can you advise if there is access to this clinical trial? If yes, can you provide contact information? My brother in law has ALS, is a veteran and has been treating at MGH along with his VA physician.


  8. My husband was diagnosed with ALS 1 year ago. He was always a happy, active, healthy and positive person. We pray every day that you doctors find a treatment for this terrible disease.

    Liked by 1 person

  9. I’m so happy my Daughter got cured of ALS which almost make her disable and taken her life, please help me in thanking this clinic for their good work by healing ALS patient, they are so great and useful to the state, they are not here to cheat on sick people but ready to help the sick, my Daughter get herself back to feet after 4 Months of medication, here is their email: if you need their help


Leave a Reply to Dewayne Bryant Cancel reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s